Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

BACKGROUND: We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear. c-Jun N-terminal kinase (JNK), a member of mito...

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Autores principales: Mei, Xiao-Peng, Zhang, Hui, Wang, Wei, Wei, Yan-Yan, Zhai, Ming-Zhu, Wang, Wen, Xu, Li-Xian, Li, Yun-Qing
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033337/
https://ncbi.nlm.nih.gov/pubmed/21255465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-6
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