Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain

BACKGROUND: Neuropathic pain (NP) continues to be challenging to treat due to lack of effective drugs. Accumulating evidence elucidated that glia-mediated inflammatory reactions play a pivotal role in the introduction and development of NP. Besides, activation of the c-Jun N-terminal kinase (JNK)/mo...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Tang, Jun, Zhu, Chao, Li, Zhi-hong, Liu, Xiao-yu, Sun, Shu-kai, Zhang, Ting, Luo, Zhuo-jing, Zhang, Hui, Li, Wei-yan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406216/
https://ncbi.nlm.nih.gov/pubmed/25889689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0279-7
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