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Activation of IFN-β expression by a viral mRNA through RNase L and MDA5
IFNs play a critical role in innate immunity against viral infections. Melanoma differentiation-associated protein 5 (MDA5), an RNA helicase, is a key component in activating the expression of type I IFNs in response to certain types of viral infection. MDA5 senses noncellular RNA and triggers the s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033319/ https://ncbi.nlm.nih.gov/pubmed/21245317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012409108 |
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