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A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice

In a phenotype-driven mutagenesis screen, a novel, dominant mouse mutation, Nmf350, caused low seizure threshold, sporadic tonic–clonic seizures, brain enlargement and ectopic neurons in the dentate hilus and molecular layer of the hippocampus. Genetic mapping implicated Akt3, one of four candidates...

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Hlavní autoři: Tokuda, Satoko, Mahaffey, Connie L., Monks, Bobby, Faulkner, Christian R., Birnbaum, Morris J., Danzer, Steve C., Frankel, Wayne N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033189/
https://ncbi.nlm.nih.gov/pubmed/21159799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq544
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