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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

There is an enormous gap between the antiproliferative and in vivo antitumor efficacy of gemcitabine in cell line-based models and its clinical efficacy. This may be due to insensitiveness of the precursor, cancer stem cell (CSC) compartment to cytotoxic agents. The hedgehog pathway is associated wi...

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Autors principals: Jimeno, Antonio, Feldmann, Georg, Suárez-Gauthier, Ana, Rasheed, Zeshaan, Solomon, Anna, Zou, Gang-Ming, Rubio-Viqueira, Belen, García-García, Elena, López-Ríos, Fernando, Matsui, William, Maitra, Anirban, Hidalgo, Manuel
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033101/
https://ncbi.nlm.nih.gov/pubmed/19174553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0924
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