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Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases
The introduction of extended-spectrum cephalosporins and β-lactamase inhibitors has driven the evolution of extended–spectrum TEM β-lactamases (ESBLs) with the ability to hydrolyze these drugs. The evolved TEM ESBLs from clinical isolates of bacteria often contain substitutions that occur in the act...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3032993/ https://ncbi.nlm.nih.gov/pubmed/20955714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.008 |
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