Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase

Even though myelodysplastic syndromes are characterized by ineffective hematopoiesis, the molecular alterations that lead to marrow failure have not been well elucidated. We have previously shown that the myelosuppressive TGF-β pathway is constitutively activated in MDS progenitors. Since there is c...

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Autori principali: Zhou, L, McMahon, C, Bhagat, T, Alencar, C, Yu, Y, Fazzari, M, Sohal, D, Heuck, C, Gundabolu, K, Ng, C, Mo, Y, Shen, W, Wickrema, A, Kong, G, Friedman, E, Sokol, L, Mantzaris, G, Pellagatti, A, Boultwood, J, Platanias, LC., Steidl, U, Yan, L, Yingling, JM, Lahn, MM, List, A, Bitzer, M, Verma, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032816/
https://ncbi.nlm.nih.gov/pubmed/21189329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2933
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