Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins

In an attempt to improve TRAIL's (tumor necrosis factor-related apoptosis-inducing ligand) tumor selective activity a variant was designed, in which the three TRAIL protomers are expressed as a single polypeptide chain (scTRAIL). By genetic fusion with a single-chain antibody fragment (scFv) re...

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Hlavní autoři: Schneider, B, Münkel, S, Krippner-Heidenreich, A, Grunwald, I, Wels, W S, Wajant, H, Pfizenmaier, K, Gerspach, J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032523/
https://ncbi.nlm.nih.gov/pubmed/21364672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.45
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