Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominan...

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Detalhes bibliográficos
Main Authors: Lei, W-W, Zhang, K-H, Pan, X-C, Wang, D-M, Hu, Y, Yang, Y-N, Song, J-G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032309/
https://ncbi.nlm.nih.gov/pubmed/21364650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.21
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