TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

The role of a small transforming growth factor beta (TGF-β)-induced TIAF1 (TGF-β1-induced antiapoptotic factor) in the pathogenesis of Alzheimer's disease (AD) was investigated. TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation...

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Autori principali: Lee, M-H, Lin, S-R, Chang, J-Y, Schultz, L, Heath, J, Hsu, L-J, Kuo, Y-M, Hong, Q, Chiang, M-F, Gong, C-X, Sze, C-I, Chang, N-S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032296/
https://ncbi.nlm.nih.gov/pubmed/21368882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.83
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