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Three clusters of conformational states in P450cam reveal a multi-step pathway for closing of the substrate access channel,
Conformational changes in the substrate access channel have been observed for several forms of cytochrome P450, but the extent of conformational plasticity exhibited by a given isozyme has not been completely characterized. Here we present crystal structures of P450cam bound to a library of 12 activ...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3032038/ https://ncbi.nlm.nih.gov/pubmed/21171581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101726d |
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