Attenuated reovirus displays oncolysis with reduced host toxicity

BACKGROUND: Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart,...

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Main Authors: Kim, M, Garant, K A, zur Nieden, N I, Alain, T, Loken, S D, Urbanski, S J, Forsyth, P A, Rancourt, D E, Lee, P W K, Johnston, R N
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031901/
https://ncbi.nlm.nih.gov/pubmed/21179029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606053
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