Attenuated reovirus displays oncolysis with reduced host toxicity

BACKGROUND: Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart,...

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Bibliografische gegevens
Hoofdauteurs: Kim, M, Garant, K A, zur Nieden, N I, Alain, T, Loken, S D, Urbanski, S J, Forsyth, P A, Rancourt, D E, Lee, P W K, Johnston, R N
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
Onderwerpen:
Translational Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031901/
https://ncbi.nlm.nih.gov/pubmed/21179029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606053
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