Attenuated reovirus displays oncolysis with reduced host toxicity

BACKGROUND: Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart,...

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Bibliografiset tiedot
Päätekijät: Kim, M, Garant, K A, zur Nieden, N I, Alain, T, Loken, S D, Urbanski, S J, Forsyth, P A, Rancourt, D E, Lee, P W K, Johnston, R N
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2011
Aiheet:
Translational Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031901/
https://ncbi.nlm.nih.gov/pubmed/21179029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606053
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