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FRET Enabled Real Time Detection of RNA-Small Molecule Binding
A robust analysis and discovery platform for antibiotics targeting the bacterial rRNA A-site has been developed by incorporating a new emissive U surrogate into the RNA and labeling the aminoglycosides with an appropriate fluorescence acceptor. Specifically, a 5-methoxyquinazoline-2,4(1H,3H)-dione-b...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031783/ https://ncbi.nlm.nih.gov/pubmed/19908830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja905767g |
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