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Epistatic Interactions in Genetic Regulation of t-PA and PAI-1 Levels in a Ghanaian Population

The proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), act in concert to balance thrombus formation and degradation, thereby modulating the development of arterial thrombosis and excessive bleeding. PAI-1 is upregulated by the renin-angiotensin system (RAS),...

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Autors principals: Penrod, Nadia M., Poku, Kwabena A., Vaughn, Douglas E., Asselbergs, Folkert W., Brown, Nancy J., Moore, Jason H., Williams, Scott M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031598/
https://ncbi.nlm.nih.gov/pubmed/21304999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016639
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