Inhibition of cell adhesion by anti–P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti–P-selectin aptamer and examined...

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Bibliografiska uppgifter
Huvudupphovsmän: Gutsaeva, Diana R., Parkerson, James B., Yerigenahally, Shobha D., Kurz, Jeffrey C., Schaub, Robert G., Ikuta, Tohru, Head, C. Alvin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Vascular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031491/
https://ncbi.nlm.nih.gov/pubmed/20926770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285718
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