Inhibition of cell adhesion by anti–P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti–P-selectin aptamer and examined...

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Hlavní autoři: Gutsaeva, Diana R., Parkerson, James B., Yerigenahally, Shobha D., Kurz, Jeffrey C., Schaub, Robert G., Ikuta, Tohru, Head, C. Alvin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031491/
https://ncbi.nlm.nih.gov/pubmed/20926770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285718
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