Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3

We investigated possible cellular receptors for the human CXC chemokine platelet factor-4 variant/CXCL4L1, a potent inhibitor of angiogenesis. We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displa...

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Autori principali: Struyf, Sofie, Salogni, Laura, Burdick, Marie D., Vandercappellen, Jo, Gouwy, Mieke, Noppen, Sam, Proost, Paul, Opdenakker, Ghislain, Parmentier, Marc, Gerard, Craig, Sozzani, Silvano, Strieter, Robert M., Van Damme, Jo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031477/
https://ncbi.nlm.nih.gov/pubmed/20980681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-253591
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