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Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants

The immunomodulator drug Gilenya (FTY720), marketed as the first oral sphingosine 1-phosphate receptor (S1P-R) modulator for treatment of Multiple Sclerosis (MS) also inhibits lysosomal acid sphingomyelinase (ASMase). Treatment of cultured cells for 24h with FTY720 (up to 10μM) inhibited ASMase by &...

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Main Authors: Dawson, Glyn, Qin, Jingdong
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031124/
https://ncbi.nlm.nih.gov/pubmed/21130737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.11.115
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