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Aberrant ROCK activation promotes the development of type I diabetes in NOD mice
Aberrant production of IL-21 by T cells is critical for the development of type 1 diabetes (T1D) in NOD mice. The pathogenic effects of IL-21 are partly due to its ability to promote the generation of T(H)-17 cells. Interferon Regulatory Factor (IRF4) is a crucial regulator of IL-17 and IL-21 produc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031108/ https://ncbi.nlm.nih.gov/pubmed/21111405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2010.10.009 |
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