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Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized

We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and non-tumorigenic cells, or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly from...

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Detalhes bibliográficos
Main Authors: Quintana, Elsa, Shackleton, Mark, Foster, Hannah R., Fullen, Douglas R., Sabel, Michael S., Johnson, Timothy M., Morrison, Sean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031091/
https://ncbi.nlm.nih.gov/pubmed/21075313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.012
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