Loss of DNAM-1 contributes to CD8(+) T cell exhaustion in chronic HIV-1 infection

The hallmark of chronic viral infections is a progressive exhaustion of antigen specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunc...

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Autores principales: Cella, Marina, Presti, Rachel, Vermi, William, Lavender, Kerry, Turnbull, Emma, Ochsenbauer-Jambor, Christina, Kappes, John C., Ferrari, Guido, Kessels, Lisa, Williams, Ian, McMichael, Andrew J., Haynes, Barton F., Borrow, Persephone, Colonna, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031090/
https://ncbi.nlm.nih.gov/pubmed/20201043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200940234
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