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Lubiprostone targets prostanoid EP(4) receptors in ovine airways
BACKGROUND AND PURPOSE: Lubiprostone, a prostaglandin E(1) derivative, is reported to activate ClC-2 chloride channels located in the apical membranes of a number of transporting epithelia. Lack of functioning CFTR chloride channels in epithelia is responsible for the genetic disease cystic fibrosis...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Blackwell Publishing Ltd
2011
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031069/ https://ncbi.nlm.nih.gov/pubmed/20883477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01058.x |
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