Alteration of the pilin adhesin of Pseudomonas aeruginosa PAO results in normal pilus biogenesis but a loss of adherence to human pneumocyte cells and decreased virulence in mice.

The disulfide loop domain of Pseudomonas aeruginosa PAO pilin was altered by insertion of a chloramphenicol acetyltransferase gene into the pilin gene so that the C-terminal nine amino acids were replaced with 11 new amino acids. The altered pilin gene was transferred into wild-type PAO by recombina...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Farinha, M A, Conway, B D, Glasier, L M, Ellert, N W, Irvin, R T, Sherburne, R, Paranchych, W
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7927665/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.10.4118-4123.1994
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