Alteration of the pilin adhesin of Pseudomonas aeruginosa PAO results in normal pilus biogenesis but a loss of adherence to human pneumocyte cells and decreased virulence in mice.

The disulfide loop domain of Pseudomonas aeruginosa PAO pilin was altered by insertion of a chloramphenicol acetyltransferase gene into the pilin gene so that the C-terminal nine amino acids were replaced with 11 new amino acids. The altered pilin gene was transferred into wild-type PAO by recombina...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Farinha, M A, Conway, B D, Glasier, L M, Ellert, N W, Irvin, R T, Sherburne, R, Paranchych, W
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303085/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7927665/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.10.4118-4123.1994
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