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Dosage effect of zero to three functional LBR-genes in vivo and in vitro
The Lamin B receptor (LBR) is a pivotal architectural protein in the nuclear envelope. Mutations in the Lamin B receptor lead to nuclear hyposegmentation (Pelger-Huët anomaly). We have exactly quantified the nuclear lobulation in neutrophils from individuals with 0, 1, 2 and 3 functional copies of t...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Landes Bioscience
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030694/ https://ncbi.nlm.nih.gov/pubmed/21326950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.1.2.11113 |
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