Superior Neutralizing Antibody Response and Protection in Mice Vaccinated with Heterologous DNA Prime and Virus Like Particle Boost against HPAI H5N1 Virus

BACKGROUND: Although DNA plasmid and virus-like particle (VLP) vaccines have been individually tested against highly pathogenic avian influenza (HPAI) H5N1 viruses, the combination of both vaccines into a heterologous prime-boost strategy against HPAI H5N1 viruses has not been reported before. METHO...

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Detalhes bibliográficos
Main Authors: Ding, Heng, Tsai, Cheguo, Gutiérrez, Ramona Alikiiteaga, Zhou, Fan, Buchy, Philippe, Deubel, Vincent, Zhou, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030595/
https://ncbi.nlm.nih.gov/pubmed/21305045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016563
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