Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles

<p>Abstract</p> <p>Background</p> <p>There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial. Thi...

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Detalhes bibliográficos
Main Authors: Anson Donald S, Getty Brian, Dowall Stuart D, Dennis Mike J, Sharpe Sally A, Bridge Simon H, Skinner Michael A, Stewart James P, Blanchard Tom J
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2011-09-01
Colecção:Virology Journal
Assuntos:
Prime-boost HIV vaccine
broadly reactive neutralising antibodies
recombinant poxvirus
modified vaccinia virus Ankara
fowlpox virus
cholera toxin B
human complement protein C3d
virus-like particle
Acesso em linha:http://www.virologyj.com/content/8/1/429
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