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Inferences About the Distribution of Dominance Drawn From Yeast Gene Knockout Data
Data from several thousand knockout mutations in yeast (Saccharomyces cerevisiae) were used to estimate the distribution of dominance coefficients. We propose a new unbiased likelihood approach to measuring dominance coefficients. On average, deleterious mutations are partially recessive, with a mea...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030496/ https://ncbi.nlm.nih.gov/pubmed/21098719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.124560 |
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