Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Here, we generated and analyzed SMS1-null mice. SMS1-null mice exhibited moderate neonatal lethality, reduced body weight, and loss of fat tissues mass, suggesting that they might have metabolic abnormality. Indee...

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Autors principals: Yano, Masato, Watanabe, Ken, Yamamoto, Tadashi, Ikeda, Kazutaka, Senokuchi, Takafumi, Lu, Meihong, Kadomatsu, Tsuyoshi, Tsukano, Hiroto, Ikawa, Masahito, Okabe, Masaru, Yamaoka, Shohei, Okazaki, Toshiro, Umehara, Hisanori, Gotoh, Tomomi, Song, Wen-Jie, Node, Koichi, Taguchi, Ryo, Yamagata, Kazuya, Oike, Yuichi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030399/
https://ncbi.nlm.nih.gov/pubmed/21115496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179176
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