Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

We present here a study of a eukaryotic trans-prenylsynthase from the malaria pathogen Plasmodium vivax. Based on the results of biochemical assays and contrary to previous indications, this enzyme catalyzes the production of geranylgeranyl pyrophosphate (GGPP) rather than farnesyl pyrophosphate (FP...

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Autores principales: Artz, Jennifer D., Wernimont, Amy K., Dunford, James E., Schapira, Matthieu, Dong, Aiping, Zhao, Yong, Lew, Jocelyne, Russell, R. Graham G., Ebetino, F. Hal, Oppermann, Udo, Hui, Raymond
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030337/
https://ncbi.nlm.nih.gov/pubmed/21084289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027235
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