A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach.

The urease of Helicobacter pylori has been proposed to be one of its pathogenic factors. A kanamycin resistance determinant was inserted in a cloned urease gene, and transformation-mediated allelic exchange mutagenesis was carried out to introduce the disrupted gene into the corresponding wild-type...

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Bibliografische gegevens

Gepubliceerd in:	Infect Immun
Hoofdauteurs:	Tsuda, M, Karita, M, Morshed, M G, Okita, K, Nakazawa, T
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1994
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8039935/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.8.3586-3589.1994
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