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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature aging disorder Werner syndrome. A small molecule from the Nat...

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Bibliografiske detaljer
Main Authors: Aggarwal, Monika, Sommers, Joshua A., Shoemaker, Robert H., Brosh, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029756/
https://ncbi.nlm.nih.gov/pubmed/21220316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006423108
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