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Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump

Crystal structures in both oxidized and reduced forms are reported for two bacterial cytochrome c oxidase mutants that define the D and K proton paths, showing conformational change in response to reduction and the loss of strategic waters that can account for inhibition of proton transfer. In the o...

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Autors principals: Liu, Jian, Qin, Ling, Ferguson-Miller, Shelagh
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029696/
https://ncbi.nlm.nih.gov/pubmed/21205904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012846108
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