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A Conserved Steroid Binding Site in Cytochrome c Oxidase,

Micromolar concentrations of the bile salt deoxycholate are shown to rescue the activity of an inactive mutant, E101A, in the K proton pathway of Rhodobacter sphaeroides cytochrome c oxidase. A crystal structure of the wild-type enzyme reveals, as predicted, deoxycholate bound with its carboxyl grou...

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Bibliographic Details
Main Authors: Qin, Ling, Mills, Denise A., Buhrow, Leann, Hiser, Carrie, Ferguson-Miller, Shelagh
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659358/
https://ncbi.nlm.nih.gov/pubmed/18759498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8013483
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