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A Conserved Steroid Binding Site in Cytochrome c Oxidase,
Micromolar concentrations of the bile salt deoxycholate are shown to rescue the activity of an inactive mutant, E101A, in the K proton pathway of Rhodobacter sphaeroides cytochrome c oxidase. A crystal structure of the wild-type enzyme reveals, as predicted, deoxycholate bound with its carboxyl grou...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659358/ https://ncbi.nlm.nih.gov/pubmed/18759498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8013483 |
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