Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

BACKGROUND: We previously reported that the immunogenicity of Hcβtre, a botulinum neurotoxin A (BoNT/A) immunogen, was enhanced by fusion to an epithelial cell binding domain, Ad2F, when nasally delivered to mice with cholera toxin (CT). This study was performed to determine if Ad2F would enhance th...

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Главные авторы: Staats, Herman F., Fielhauer, Jeffrey R., Thompson, Afton L., Tripp, Alice A., Sobel, Ashley E., Maddaloni, Massimo, Abraham, Soman N., Pascual, David W.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029387/
https://ncbi.nlm.nih.gov/pubmed/21304600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016532
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