Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

BACKGROUND: We previously reported that the immunogenicity of Hcβtre, a botulinum neurotoxin A (BoNT/A) immunogen, was enhanced by fusion to an epithelial cell binding domain, Ad2F, when nasally delivered to mice with cholera toxin (CT). This study was performed to determine if Ad2F would enhance th...

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Detaylı Bibliyografya
Asıl Yazarlar: Staats, Herman F., Fielhauer, Jeffrey R., Thompson, Afton L., Tripp, Alice A., Sobel, Ashley E., Maddaloni, Massimo, Abraham, Soman N., Pascual, David W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029387/
https://ncbi.nlm.nih.gov/pubmed/21304600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016532
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