Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

BACKGROUND: We previously reported that the immunogenicity of Hcβtre, a botulinum neurotoxin A (BoNT/A) immunogen, was enhanced by fusion to an epithelial cell binding domain, Ad2F, when nasally delivered to mice with cholera toxin (CT). This study was performed to determine if Ad2F would enhance th...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Staats, Herman F., Fielhauer, Jeffrey R., Thompson, Afton L., Tripp, Alice A., Sobel, Ashley E., Maddaloni, Massimo, Abraham, Soman N., Pascual, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029387/
https://ncbi.nlm.nih.gov/pubmed/21304600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016532
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi