Prostaglandin E(2) Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression

INTRODUCTION: B cells may play an important role in promoting immune activation in the rheumatoid synovium and can produce prostaglandin E(2) (PGE(2)) when activated. In its turn, PGE(2) formed by cyclooxygenase (COX) and microsomal prostaglandin E(2) synthase 1 (MPGES1) contributes to the rheumatoi...

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Detalhes bibliográficos
Main Authors: Gheorghe, Karina Roxana, Thurlings, Rogier M., Westman, Marie, Boumans, Maartje J., Malmström, Vivianne, Trollmo, Christina, Korotkova, Marina, Jakobsson, Per-Johan, Tak, Paul-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029314/
https://ncbi.nlm.nih.gov/pubmed/21298002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016378
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