Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells

BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C)) to the pathogenic one (PrP(Sc)). The pathogenic mechanisms and the subcellular sites of the conversion are not c...

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Главные авторы: Wang, Xin, Shi, Qi, Xu, Kun, Gao, Chen, Chen, Cao, Li, Xiao-Li, Wang, Gui-Rong, Tian, Chan, Han, Jun, Dong, Xiao-Ping
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029303/
https://ncbi.nlm.nih.gov/pubmed/21298055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014602
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