Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs.

The catalytic A subunit of cholera toxin (CT-A) is capable of ADP-ribosylating the guanine nucleotide-binding protein, which regulates cell adenylyl cyclase, leading to the life-threatening diarrhea of cholera. Amino acids involved in the enzymatic activity of CT-A have previously been identified. B...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Häse, C C, Thai, L S, Boesman-Finkelstein, M, Mar, V L, Burnette, W N, Kaslow, H R, Stevens, L A, Moss, J, Finkelstein, R A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8039872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.8.3051-3057.1994
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