Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs.

The catalytic A subunit of cholera toxin (CT-A) is capable of ADP-ribosylating the guanine nucleotide-binding protein, which regulates cell adenylyl cyclase, leading to the life-threatening diarrhea of cholera. Amino acids involved in the enzymatic activity of CT-A have previously been identified. B...

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Autori principali: Häse, C C, Thai, L S, Boesman-Finkelstein, M, Mar, V L, Burnette, W N, Kaslow, H R, Stevens, L A, Moss, J, Finkelstein, R A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC302926/
https://ncbi.nlm.nih.gov/pubmed/8039872
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