A Cardinal Role for Cathepsin D in Co-Ordinating the Host-Mediated Apoptosis of Macrophages and Killing of Pneumococci

The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of...

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Detalhes bibliográficos
Main Authors: Bewley, Martin A., Marriott, Helen M., Tulone, Calogero, Francis, Sheila E., Mitchell, Timothy J., Read, Robert C., Chain, Benny, Kroemer, Guido, Whyte, Moira K. B., Dockrell, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029254/
https://ncbi.nlm.nih.gov/pubmed/21298030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001262
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