A phase 1 study of a 2 day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound paclitaxel for advanced solid malignancies

PURPOSE: Systemic chemotherapy fails to access much of the tumor burden in patients with advanced cancer, significantly limiting its efficacy. In preclinical studies, brief high doses of tyrosine kinase inhibitors (TKIs) targeting the Human Epidermal Growth Factor Receptor (HER) family can prime tum...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chien, AJ, Illi, JA, Ko, AH, Korn, WM, Fong, L, Chen, LM, Kashani-Sabet, M, Ryan, C, Rosenberg, J, Dubey, S, Small, EJ, Jahan, TM, Hylton, NM, Yeh, BM, Huang, Y, Koch, KM, Moasser, MM
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029022/
https://ncbi.nlm.nih.gov/pubmed/19706807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0522
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires