Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo

AIMS: High-mobility group box 1 (HMGB1) is a nuclear protein actively secreted by immune cells and passively released by necrotic cells that initiates pro-inflammatory signalling through binding to the receptor for advance glycation end-products. HMGB1 has been established as a key inflammatory medi...

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Main Authors: Loukili, Noureddine, Rosenblatt-Velin, Nathalie, Li, Jianhui, Clerc, Stéphanie, Pacher, Pal, Feihl, François, Waeber, Bernard, Liaudet, Lucas
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Original Articles: Focus on Inorganic Nitrite and Nitrate
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028979/
https://ncbi.nlm.nih.gov/pubmed/21113057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq373
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