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Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation

Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of Gag. The FV Pol precursor is cleaved only once between reverse transcriptase (RT) and integrase (IN) by the protease (PR), resulting in a PR-RT and an IN protein. Only the Pol precursor, not the cleaved subunits, is pa...

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Hlavní autoři: Lee, Eun-Gyung, Roy, Jacqueline, Jackson, Dana, Clark, Patrick, Boyer, Paul L., Hughes, Stephen H., Linial, Maxine L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028899/
https://ncbi.nlm.nih.gov/pubmed/21123385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01873-09
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