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Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation

Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of Gag. The FV Pol precursor is cleaved only once between reverse transcriptase (RT) and integrase (IN) by the protease (PR), resulting in a PR-RT and an IN protein. Only the Pol precursor, not the cleaved subunits, is pa...

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Bibliografske podrobnosti
Main Authors: Lee, Eun-Gyung, Roy, Jacqueline, Jackson, Dana, Clark, Patrick, Boyer, Paul L., Hughes, Stephen H., Linial, Maxine L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028899/
https://ncbi.nlm.nih.gov/pubmed/21123385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01873-09
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