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The Activator Protein 1 Binding Motifs within the Human Cytomegalovirus Major Immediate-Early Enhancer Are Functionally Redundant and Act in a Cooperative Manner with the NF-κB Sites during Acute Infection

Human cytomegalovirus (HCMV) infection causes a rapid induction of c-Fos and c-Jun, the major subunits of activator protein 1 (AP-1), which in turn have been postulated to activate the viral immediate-early (IE) genes. Accordingly, the major IE promoter (MIEP) enhancer, a critical control region for...

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Hlavní autoři: Isern, Elena, Gustems, Montse, Messerle, Martin, Borst, Eva, Ghazal, Peter, Angulo, Ana
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028895/
https://ncbi.nlm.nih.gov/pubmed/21106746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01713-10
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