Elimination of ie1 Significantly Attenuates Murine Cytomegalovirus Virulence but Does Not Alter Replicative Capacity in Cell Culture

The major immediate-early (MIE) genes of cytomegaloviruses (CMV) are broadly thought to be decisive regulators of lytic replication and reactivation from latency. To directly assess the role of the MIE protein IE1 during the infection of murine CMV (MCMV), we constructed an MCMV with exon 4 of the i...

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Detalhes bibliográficos
Main Authors: Ghazal, Peter, Visser, Astrid E., Gustems, Montse, García, Rosalía, Borst, Eva Maria, Sullivan, Kevin, Messerle, Martin, Angulo, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112098/
https://ncbi.nlm.nih.gov/pubmed/15890957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.7182-7194.2005
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