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Elimination of ie1 Significantly Attenuates Murine Cytomegalovirus Virulence but Does Not Alter Replicative Capacity in Cell Culture

The major immediate-early (MIE) genes of cytomegaloviruses (CMV) are broadly thought to be decisive regulators of lytic replication and reactivation from latency. To directly assess the role of the MIE protein IE1 during the infection of murine CMV (MCMV), we constructed an MCMV with exon 4 of the i...

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書誌詳細
主要な著者: Ghazal, Peter, Visser, Astrid E., Gustems, Montse, García, Rosalía, Borst, Eva Maria, Sullivan, Kevin, Messerle, Martin, Angulo, Ana
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112098/
https://ncbi.nlm.nih.gov/pubmed/15890957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.7182-7194.2005
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