Elimination of ie1 Significantly Attenuates Murine Cytomegalovirus Virulence but Does Not Alter Replicative Capacity in Cell Culture

The major immediate-early (MIE) genes of cytomegaloviruses (CMV) are broadly thought to be decisive regulators of lytic replication and reactivation from latency. To directly assess the role of the MIE protein IE1 during the infection of murine CMV (MCMV), we constructed an MCMV with exon 4 of the i...

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Bibliografiska uppgifter
Huvudupphovsmän: Ghazal, Peter, Visser, Astrid E., Gustems, Montse, García, Rosalía, Borst, Eva Maria, Sullivan, Kevin, Messerle, Martin, Angulo, Ana
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112098/
https://ncbi.nlm.nih.gov/pubmed/15890957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.7182-7194.2005
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