Cell Type Specificity and Host Genetic Polymorphisms Influence Antibody-Dependent Enhancement of Dengue Virus Infection

Antibody-dependent enhancement (ADE) is implicated in severe, usually secondary, dengue virus (DV) infections. Preexisting heterotypic antibodies, via their Fc-gamma receptor (FcγR) interactions, may increase disease severity through enhanced target cell infection. Greater numbers of infected target...

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Autori principali: Boonnak, Kobporn, Dambach, Kaitlyn M., Donofrio, Gina C., Tassaneetrithep, Boonrat, Marovich, Mary A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028884/
https://ncbi.nlm.nih.gov/pubmed/21123382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00220-10
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