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Thrombopoietin Contributes to Neuronal Damage in Experimental Bacterial Meningitis

Thrombopoietin (Tpo), which primarily regulates megakaryopoiesis, and its receptor (c-Mpl) are expressed in the brain, where Tpo exhibits proapototic effects on neurons. In the present study, we investigated the implication of Tpo in experimental pneumococcal meningitis. Following intrathecal infect...

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Detalhes bibliográficos
Main Authors: Hoffmann, Olaf, Rung, Olga, Im, Ae-Rie, Freyer, Dorette, Zhang, Juan, Held, Josephin, Stenzel, Werner, Dame, Christof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028827/
https://ncbi.nlm.nih.gov/pubmed/21149592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00782-10
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