Alkylated Porphyrins Have Broad Antiviral Activity against Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses

We screened ∼2,200 compounds known to be safe in people for the ability to reduce the amount of virion-associated hepatitis B virus (HBV) DNA in the culture medium of producer cells. These efforts led to the discovery of an alkylated porphyrin, chlorophyllide, as the compound that achieved the great...

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Main Authors: Guo, Haitao, Pan, Xiaoben, Mao, Richeng, Zhang, Xianchao, Wang, Lijuan, Lu, Xuanyong, Chang, Jinhong, Guo, Ju-Tao, Passic, Shendra, Krebs, Fred C., Wigdahl, Brian, Warren, Travis K., Retterer, Cary J., Bavari, Sina, Xu, Xiaodong, Cuconati, Andrea, Block, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028764/
https://ncbi.nlm.nih.gov/pubmed/21135183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00989-10
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